What is NAD+?

Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme present in every living cell and involved in many metabolic processes related to cellular energy. It’s often studied in the context of aging, cancer, and neurodegenerative and metabolic disorders.

(This guide is specifically about NAD+ injections/IV, not NMN or NR oral supplements.)

General Dosing Principles (Subcutaneous NAD+)

Key ideas:

• There is no one-size-fits-all dosing approach.
• The suggested strategy is:
  • Start low, see how the individual responds.
  • Taper up based on response.
  • Aim for the minimum effective dose where benefits are noticed with no or tolerable side effects.
• “Microdose / test dose” is recommended for those who tend to be very sensitive to exogenous compounds (e.g., people with MOLD, CIRS, Lyme, autoimmune conditions, MCAS, high chemical sensitivity).
• The more chemically sensitive someone is, the lower the initial test dose should be.

NAD+ Subcutaneous Injection Dose Ranges

SubQ dosing ranges (per injection):

• “Microdose” / Test Dose: 10–25 mg
• Low–Moderate Dose: 25–50 mg
• Moderate Dose: 50–75 mg
• Moderate–Moderate High: 75–100 mg
• High: 100–125 mg
• Upper End: 125–150+ mg

Many people reportedly notice an energy boost in the 50–100 mg range, often within the first week, but responses vary.

Titration Method to Find an Effective Dose

Example of a gradual titration approach: